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Polychlorinated biphenyls (PCBs) were banned from manufacture in 1979 but persist in the environment and strongly bind to sediments. Lower chlorinated PCBs (LC-PCBs), defined as four or less chlorines per PCB and the most volatile PCBs, more easily transport from sediment into the air than higher chlorinated PCBs. Expo...
This dissertation contextualizes the sensory designs of natural and artificial caves with hydraulic features that were embedded into Roman villas in Italy from the second century BCE to the second century CE. These grottoes were decorated with architectural elements, stuccoes, mosaics, paintings, and/or sculptures that...
11. Sustainability8. Economic growthhistory and archaeologyhumanities and the arts
Target-mediated drug disposition (TMDD) is generally described as a pharmacokinetic (PK) phenomenon in which drug disposition is significantly influenced by a substantial fraction of drug molecules (relative to the administered dose) binding to a high-affinity and low-capacity pharmacological target. TMDD can occur in...
Circular RNAs (circRNAs) are a class of RNA molecule formed by a process called backsplicing, where a downstream splice-site joins with an upstream splice-site forming a covalently closed loop structure. CircRNAs are highly expressed and evolutionarily conserved across species. The gene locus of muscleblind (mbl) under...
This dissertation investigates two critical economic challenges: global public health emergencies and the transformation of the digital economy. Through the development and application of state-of-the-art computational economics and machine learning methodologies, it provides an in-depth analysis of market behavior, po...
Conversely to the western-style diet, other diet patterns with higher fiber and plant content are often associated with better outcomes and lower incidence of MS. One class of dietary compounds that can be found in many of these diets is isoflavones, a type of phytoestrogen. Previous work from our lab showed that isofl...
Individual differences in cortical morphology, specifically tertiary sulci like the posterior middle frontal sulci (pmfs), are obscured by standard template-based neuroimaging approaches, yet may be key to explaining variability in age-related executive function (EF) decline. pmfs develop late in gestation, mature thro...
Frequency distributions of learning patterns showed variation across contexts. Descriptively, Abstract Conceptualization and Reflective Observation means fell below the published normative values, while Active Experimentation means exceeded the normative sample in both contexts, highlighting an experience and action-or...
Carbon (C), nitrogen (N), and sulfur (S) are essential macronutrients required for plant growth and development. Inorganic C, N, and S are acquired from the atmosphere or soil and assimilated into sucrose and amino acids within source organs. These assimilates are used in source metabolism or loaded into the plant vasc...
In Chapter 4, I summarize the main conclusions of this dissertation and outline directions for future work. Overall, these studies show that ULK1 and ULK2 are central coordinators of skeletal muscle proteostasis, acting at the intersection of protein synthesis and autophagy. Lifelong or postnatal loss of ULK1/2 uncoupl...
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