Buscador de Tesis y publicaciones académicas

Modulating microRNAs to prevent to emergence of drug resistance

Simmons, Nina Ann Grogan

Lung adenocarcinoma frequently harbours specific oncogene driver mutations which can be treated with targeted therapies. The development of drug resistance commonly occurs following treatment however, leading to poor survival outcomes. Drug tolerance is a non-genetic and reversible adaptive state adopted by a small num...

SULT1A1 Inhibition and the Prevention of BRCA1-Associated Breast Cancer

Young, Emily Grace

Breast cancer is the most common malignancy among women worldwide, with approximately 2.3 million women diagnosed and 685,000 deaths reported in 2020. It is a genetically and clinically heterogeneous disease comprising multiple subtypes that influence prognosis and treatment strategies. Hereditary breast cancer is most...

Influence of biological sex on the microbiome in periodontal health and disease

Rubinov, Aleksandr

Sex is a well-established factor in the pathogenesis of systemic inflammatory diseases, yet its role in shaping the oral microbiome remains underexplored. Periodontitis, a chronic inflammatory disease of the supporting structures of the teeth, is influenced by both microbial dysbiosis and host response. While sex diffe...

A long Impatience

Dunnahoo, Katie

A poetry anthology as a poetic en/counter-form

Alves Santos, Gleisson

Percussion Hills

Greig, Audrey Rhonda

This thesis is a poetic memoir of the author/artist Rhondda Greig and her family past and contemporary.

The Effects of Solanum sisymbriifolium on the Columbia Root-knot Nematode Meloidogyne chitwoodi

Chandler, Koy Owen

Plant parasitic nematodes (PPNs) are among some of the most devastating pests and cause large economic losses to many cropping systems around the world. While the most common and prominent control method is soil fumigation, it is very expensive, impacts soil health, and is becoming increasingly regulated. Thus, it is i...

Iconographic Expressions of Vaiśravaṇa in Tibetan Buddhist Art: An Analysis from Butön Rinchen Drub in the Fourteenth-Century Shalu Monastery

Qian, Yincheng

This thesis explores developments in the iconography of Vaiśravaṇa that took place between the fourteenth and the eighteenth centuries in Tibetan Buddhist art. The iconographic analysis of dated murals from Shalu Monastery and Derge Parkhang (Ganzi prefecture, Sichuan) murals, Dunhuang scroll paintings, and twentieth-c...

Investigating the effect of type I interferons and butyrate on epithelial function in Crohn’s disease organoids

King, Mikayla Renee

Inflammatory bowel diseases (IBD), such as Crohn’s disease (CD) and ulcerative colitis, are chronic inflammatory conditions that target the intestinal epithelial cells (IEC), driving barrier dysfunction, impaired epithelial turnover events, and altered mucous secretion. Patients with IBD that are non-responsive (NR) to...

Developing Experimental Tools to Track Intracellular Human Peroxiredoxin 2 Oligomerisation Dynamics

Willans, Jessica Anne

Peroxiredoxins (Prx) are important antioxidant enzymes, acting to reduce peroxides, including hydrogen peroxide (H2O2) in cells. High concentrations of these peroxides can be toxic to cells and are thought to lead to various diseases including cancer and cardiovascular disease. Despite its detrimental effects, cells st...