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Comparatively, the C–H bonds of aldehydes are somewhat weaker (about 90 kcal/mol). Multiple reports have been published utilizing aldehydes to generate acyl radicals; a common method to generate these radicals proceeds via a hydrogen-atom transfer (HAT) pathway. Chapter 3 showcases multiple examples of HAT pathways inv...
Interleukin-1α is a pleiotropic cytokine that plays a pivotal role in triggering tumor-associated inflammation. Its expression is upregulated in multiple solid malignancies, including head and neck squamous cell carcinoma (HNSCC), and it has been associated with a more aggressive tumor phenotype with poor clinical outc...
Reactive Oxygen Species (ROS)Subcellular localizationHead and Neck Squamous Cell Carcinoma (HNSCC)Interleukin-1 alpha (IL-1α)
Transient subclinical perceptual events and odd thinking known as psychotic-like experiences (PLEs) can commonly manifest in children. In rare instances when PLEs are persistent or distressful, they may indicate high risk for later psychotic illness, such as schizophrenia. Numerous neurobiological and environmental mod...
I examine how exposure to retail investors who do not participate in shareholder voting affects firms’ governance activities. This issue is important because most retail investors do not participate in voting due to the time, effort, and opportunity costs of voting. My analyses leverage decisions by Charles Schwab and...
Corporate GovernanceRetail InvestorsShareholder Votingeconomics and business
Ultraviolet (UV) light is one of the most ubiquitous exogenous DNA damaging agents and is the primary etiological agent in skin cancers such as melanoma. UV light from the sun can be directly absorbed by DNA to induce helix-distorting lesions between neighboring pyrimidine bases, including cyclobutane pyrimidine dimers...
basic medicinemedical and health sciencestranscription factor bindingUV damage
In this thesis, we investigated the LDTs and 3-3 crosslinking in C. difficile. We discovered that VanW domains are a novel class of LDTs. Additionally, we found that 3-3 crosslinks and the LDTs are essential for viability in C. difficile, making it the first organism in which LDTs were shown to be essential. Loss of th...
This national study investigated 254 Australian teachers’ reported practices and perspectives regarding the use of both decontextualised synthetic phonics instruction and contextualised analytic phonics instruction in Foundation – Year 3 classrooms. The study used a mixed-methods, quan-QUAL approach with data collected...
Second, we fabricated the same formulation from a 1.5 mL and a 0.3 mL precursor solution to make relatively thick and thin nanofiber layers, respectively, exposed these thick and thin nanofiber layers repeatedly to two different loadings of bioaerosols containing either E. coli (1.8 × 1010 and 5.8 × 107 CFU/mL) or bact...
hydrophobic and antimicrobialpathogen eliminationrepeated aerosol exposuresself-decontaminating PPE
Three research questions guided this study. 1) How did Asian American college students at UI understand panethnicity from 1998-2008? 2) How did Asian American students at UI engage in student activism from 1998-2008? 3) How did gender influence Asian American student activism at UI from 1998-2008? Through these questio...
Asian American StudentsOral HistoryHistory of EducationHigher Education
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