Buscador de Tesis y publicaciones académicas

Valorisation et amélioration de l'usage du bambou dans les pratiques constructives locales du Mayombe, mécanisme de développement d'une architecture néo-vernaculaire située.

Matsuela Mbungu, Arlette

La présente thèse se propose d’analyser de manière critique et approfondie l’usage du bambou dans les pratiques constructives vernaculaires du territoire de Tshela dans la province du Kongo Central, en République Démocratique du Congo. Elle vise à interroger les logiques d’appropriation locales, les savoir-faire techni...

Dissect the tumor microenvironment to battle cancer radioresistance and immune escape

Ana Manuela Canha Borges

Implicações educativas do populismo em Portugal: das atitudes individuais às narrativas coletivas nas redes sociais

Ricardo Daniel Gonçalves Soares

O atual contexto português - marcado pela crescente visibilidade do populismo de direita- radical e pela aproximação dos/as jovens aos seus discursos - apela a que a investigação, incluindo a investigação em educação, contribua para uma compreensão mais profunda deste fenómeno, considerando as suas implicações educativ...

Health Workforce and Quality: Understanding the Foundation of Effective Care Delivery

Zhang, Lujia

Despite major advances in healthcare access worldwide, ensuring delivery of high-quality care remains a central challenge across all health system contexts. In both low- and middle-income and high-income settings, systemic challenges, ranging from inadequate resources and training support to time pressures, burnout, an...

HUMAN-AI DECISION-MAKING

DiSorbo, Matthew

It is critical to identify, and address, bottlenecks in human-AI decision-making. If not, the theoretical gains of AI may remain theoretical. In this dissertation, I will discuss three papers with that central research goal. Two study traditional decision support systems (human as the primary decision maker equipped wi...

Mechanisms of response and resistance to KRAS inhibition in pancreatic cancer

Dilly, Julien

Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal and treatment-refractory malignancy. Despite its clinical heterogeneity and complexity, PDAC displays a strikingly uniform mutational landscape dominated by alterations in the tumor suppressor genes TP53, CDKN2A, SMAD4, and by oncogenic mutations in KRAS, found...

Gender Inequality and the Changing Landscape of Economic Opportunity

Cricco, Nino Jose

Children often reproduce their parents' economic (dis)advantages when they become adults, but through different pathways. Gender conditions these pathways, limiting women’s chances at maintaining or improving upon their economic conditions through the labor market, where they tend to earn less than men. Instead, women...

Nucleotide Sponges and Evasion of Antiviral Immunity

Chang, Renee Bridget

The ability of a cell to sense and eliminate viral infection is an essential process conserved across domains of life. Nucleotide-based signaling is a central mechanism of antiviral immunity and, surprisingly, core components of animal immunity, including the cGAS-STING pathway, evolved billions of years ago in bacteri...

Optimal Market Making in Prediction Markets: Empirical Distribution Learning, Analytical Policy Characterization, and Reinforcement Learning

Jain, Nikhil

When should a market maker quote given fill probabilities, queue-clearing dynamics, and adverse-selection risk estimated from real market data? Understanding this question better allows us to understand optimal market making in prediction markets. In this thesis, we attempt to answer this question in the setting of NBA...

Interrogating the role of type I interferon in the dysregulation of AhR activity in systemic lupus erythematosus

Mudaliar, Samriti Balaji

Systemic lupus erythematosus (SLE) is an autoimmune disorder driven by aberrant B cell-helper T follicular helper (Tfh) cells and T peripheral helper (Tph) cells that promote autoantibody production by chronically active B cells. In healthy conditions, aryl hydrocarbon receptor (AhR) regulates a T helper cell phenotypi...