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Tesis doctoral 2026

Uncovering the Truth of Extraction: Global Environmental Fiction and Nonfiction, 1962–2022

Galli, Mary Kathryn

This dissertation examines global environmental fiction and nonfiction since the 1960s to assess how writers portray energy and resource extraction, including coal, uranium, oil, and critical minerals. Focusing on the overlaps between fiction and nonfiction genres, I argue that there is a trend in contemporary literatu...

ecocriticism environmental literature languages and literature contemporary
  • United States
  • English
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Tesis doctoral 2026

Identification and Characterization of a Cryptic Allosteric Site on the E3 Ligase Adapter Protein Cereblon

Dippon, Vanessa Narin

Cereblon (CRBN) is the target of thalidomide derivatives that achieve therapeutic efficacy against some hematologic neoplasias by recruiting neosubstrates for degradation. These findings have motivated scientists in the field of targeted protein degradation to hijack CRBN by designing small molecules that bind to CRBN’...

Cancer Therapeutics Chemistry Chemical Biology Targeted Protein Degradation
  • United States
  • English
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Tesis doctoral 2026

Comprehensive Flight Software Design and Validation for the Harvard CubeSat I Mission

Davis, Madison

This thesis analyzes the software architecture, development decisions, and testing procedures of the Harvard Undergraduate CubeSat (HUCSat), a six-year student-led nanosatellite project dedicated to evaluating the economic and practical viability of nitinol shape memory alloys to rotate solar panels. Section 1 provides...

mechanical engineering Satellite Computer engineering Physics
  • United States
  • English
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Tesis doctoral 2026

Tissue-Level Dynamics and Molecular Regulation of the Glucagon-like Hormone/GPCR signaling Pathway

Ahmad, Muhammad

In Drosophila melanogaster, adipokinetic hormone (AKH), a functional homolog of mammalian glucagon, acts on its receptor (AkhR) in the fat body to mobilize energy/lipid stores during increased energy demand. Despite the physiological importance of AKH/AkhR signaling, the systemic cues that trigger AKH release, the tiss...

basic medicine medical and health sciences Molecular biology Adipokinetic Hormone (AKH)
  • United States
  • English
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Tesis doctoral 2026

Deciphering the relationships between climate change, plant root exudation, and the terrestrial carbon sink

Chari, Nikhil R

Soil is the largest terrestrial carbon sink, and soil carbon storage is governed by the movement of carbon from the atmosphere into soil via plants. Most plant carbon inputs to soil – like leaf litter, root litter, or coarse woody debris – must undergo decomposition by soil microbes before they can impact soil carbon s...

agriculture, forestry, and fisheries agricultural and veterinary sciences Biology
  • United States
  • English
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Tesis doctoral 2026

Characterizing and targeting autophagy initiation via ULK1 in a tauopathy context

Murray, Heide Fellenzer Baron

Tauopathies are neurodegenerative diseases defined by the accumulation of pathological tau protein and currently lack effective disease-modifying therapies. Autophagy is an endogenous cellular pathway capable of clearing aggregation-prone proteins, but its broad pharmacological activation is limited by off-target effec...

Organoid Tauopathy iPSC Autophagy
  • United States
  • English
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Tesis doctoral 2026

What Makes Something Feel like it Fits in Mixed Reality

Mandelbrot, Jacob Marc

Mixed Reality (MR) allows digital objects to coexist in the physical world, but many MR experiences fail to achieve coherence, leaving virtual elements that feel out of place. This thesis investigates what visual and environmental factors a developer can modify to make virtual objects feel like they “fit” within a MR e...

social sciences Mixed Reality Computer Graphics psychology and cognitive sciences
  • United States
  • English
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Tesis doctoral 2026

Evaluating Graph Neural Network Performance on the Multi-Layer Contextual Stochastic Block Model

Liu, Alice Leshui

Many networks contain multiple views of the data, which occur when you have one set of vertices with multiple sets of edges that connect them. These multiple sets of edges represent different sets of relationships between the vertices and can be a potent source of information about the underlying groupings of the nodes...

multilayer stochastic block model contextual stochastic block model Statistics graph neural network
  • United States
  • English
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Tesis doctoral 2026

Investigating Amino Acid Regulation in T cells

Johnson, Sheila

Amino acids are fundamental to cellular homeostasis and have emerged as critical regulators of T cell activation, differentiation, and effector function. Despite their importance, the specific requirements and temporal dynamics of amino acid utilization in distinct T cell subsets remain incompletely understood. This di...

medical and health sciences clinical medicine Immunology Cellular biology
  • United States
  • English
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Tesis doctoral 2026

DEVELOPMENT AND EVALUATION OF A MULTIDISCIPLINARY TEAM DELIVERED DEPRESCRIBING INTERVENTION FOR PATIENTS WITH CHRONIC KIDNEY DISEASE IN QATAR

ZIDAN, AMANI

Patients with advanced stages of chronic kidney disease (CKD), particularly those undergoing hemodialysis (HD), face high rates of comorbidities and complications. With the disease progression, medication management becomes complex, and the risk of medication-related harm increases. A substantial proportion of patients...

Deprescribing Multidisciplinary Care Hemodialysis Chronic Kidney Disease
  • Qatar
  • English
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Resultados provistos por OpenAIRE, la infraestructura europea de ciencia abierta. Tesis y Másters Colombia no aloja ni distribuye estos documentos: cada enlace lleva al repositorio de origen.

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